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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A 49-year-old man presents to his physician with a 3-day acute attack of gout in four joints of the right foot. The patient has a history of at least three previous gout attacks; in one, a joint aspirate was positive for urate crystals. His history also includes type 2 diabetes mellitus and two calcium oxalate kidney stones.
Laboratory values include creatinine 3.1 mg/dL, uric acid 11.7 mg/dL, and A1C 6.8%. The patient is allergic to aspirin. Vital signs are BP135/82mm Hg and HR 90 bpm and regular.
Current medications are glipizide 10 mg daily and enalapril 20 mg daily.
Which short-term regimen is most appropriate for treating this patient's gout?

A) Indomethacin 50 mg three times daily
B) Celecoxib 200 mg daily
C) Prednisone 40 mg daily
D) Colchicine 0.6 mg hourly

2. A 25-year-old woman who is HIV-positive and has a CD4+ count of 120 cells/mm begins antiretroviral therapy. The patient's CD4+ count drops to 45 cells/mm3 over the next year. For which of the following opportunistic infections should this patient receive prophylaxis?

A) Mycobacterium tuberculosis and Pneumocystis Jirovecii pneumonia
B) Mycobacterium tuberculosis and CMV
C) MAC and Pneumocystis jirovecii pneumonia
D) MAC and Candida

3. A new team has been established in a large healthcare system to conduct research. At the first meeting of the new team, the pharmacotherapy specialist was asked to submit a proposal for a randomized clinical study. What is the first step in formulating the research hypothesis for this proposal?

A) Selecting a viable intervention
B) Determining a measurable outcome
C) Selecting an appropriate comparator
D) Formulating an answerable question

4. A 58-year-old man recently diagnosed with chronic stable angina has discontinued metoprolol due to erectile dysfunction. Medical history also includes hypertension and type 2 diabetes mellitus. The patient's current medications include aspirin, lisinopril, metformin, and sublingual nitroglycerin as needed. BP is 128/76 mm Hg, and HR 88 bpm.
Which of the following is the most appropriate choice to manage the patient's stable angina symptoms?

A) Vardenafil
B) Diltiazem CD
C) Atenolol
D) Amlodipine

5. A prospective randomized study is being developed to evaluate the effects of steroids on mortality in patients who are admitted for head injury Patients will be randomly assigned to receive 48 hours of methylprednisolone or placebo. The study will have an 80% power to detect a 2% difference in mortality. Which of the following is an appropriate null hypothesis for this study?

A) Methylprednisolone reduces mortality in head injury patients.
B) Methylprednisolone will increase mortality by 2% compared with placebo.
C) Methylprednisolone will have a 20% reduction in mortality compared with placebo.
D) Methylprednisolone and placebo are not different with respect to effect on mortality.

Solutions: