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American Society of Microbiology ABMM Sample Questions:

1. A child presents with a characteristic "slapped cheek" rash followed by a lacy, reticular rash on the trunk and extremities. The causative agent is a single-stranded DNA virus belonging to the family Parvoviridae, known as:

A) Measles virus
B) Human parvovirus B19
C) Rubella virus
D) Roseola virus (HHV-6)

2. A patient returning from a hiking trip in a Lyme disease-endemic area presents with a unilateral facial nerve palsy, headache, and neck stiffness. Serological testing for Borrelia burgdorferi by ELISA is positive, but a Western blot shows only IgM bands. The MOST appropriate interpretation of these results is:

A) The patient has a co-infection with another tick-borne pathogen causing a non-specific IgM response.
B) The patient has chronic Lyme disease with a persistent IgM response.
C) The patient has a false-positive ELISA result, and Lyme disease is unlikely.
D) The patient has early Lyme disease, and the IgM response is characteristic of recent infection.

3. A research team is investigating the development of a novel vaccine against influenza virus. They are focusing on conserved epitopes within the hemagglutinin (HA) and neuraminidase (NA) proteins to elicit broadly neutralizing antibodies. Which of the following approaches is MOST likely to achieve this goal?

A) Developing a live-attenuated influenza vaccine containing multiple serotypes.
B) Utilizing a recombinant viral vector to deliver conserved epitopes of HA and NA.
C) Designing a subunit vaccine that presents highly variable regions of HA and NA.
D) Administering high doses of inactivated influenza vaccine annually.

4. A patient with a history of travel to a rural area develops a febrile illness with myalgias and thrombocytopenia. Laboratory testing reveals the presence of morulae within circulating leukocytes. The MOST likely diagnosis is:

A) Babesiosis
B) Ehrlichiosis
C) Lyme disease
D) Anaplasmosis

5. Transmissible spongiform encephalopathies (TSEs), such as Creutzfeldt-Jakob disease (CJD) in humans and Bovine Spongiform Encephalopathy (BSE) in cattle, are caused by infectious agents composed primarily of:

A) Defective viral particles requiring a helper virus
B) Slow-growing bacteria lacking a cell wall
C) Viroids (small, circular RNA molecules)
D) Aberrantly folded host-encoded prion proteins (PrP<sup>Sc</sup>)

Solutions: